Progressive Supranuclear Palsy

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by vl151
Last updated 6 years ago

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Progressive Supranuclear Palsy

Progressive Supranuclear Palsy

Unknown pathogenesisRisk Factors: Family history and Paw-Paw fruit associated with higher incidence in the Carribean

TreatmentNo cure, no treatment to slow disease progression, and limited therapies to treat symptoms- Level 3 evidence for Physical therapy and rehabilitation to reduce falls - One case report of 60 year old man who followed walking exercise program 1 hour twice weekly for 10 years with minimal progression of problems with balance and mobility- Occupational and speech therapy - Coenzyme Q and dopaminergic drugs may improve some symptoms in some patients (level 2 evidence)

Classic PSP is characterized by: - postural instability with lurching gait and unexplained falls backwards- supranuclear vertical gaze palsy - cognitive impairment- personality change (frontal lobe symptoms)- dysphagia, dysarthria

What is it?- Uncommon neurodegenerative disorder caused by accumulations of tau protein in the brain- Reported as 6-7 cases per 100,000 persons

Prognosis- progressive course leading to death within 6-12 years of diagnosis- most patients become dependent within 3-4 years after diagnosis- many patients become wheelchair bound due to motor and visual problems causing falls and fractures


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