[2015] Henry Plaster (BIOTECH Sp 2015): Polydactyly

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by raptorkerry
Last updated 6 years ago

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[2015] Henry Plaster (BIOTECH Sp 2015): Polydactyly

Polydactyly

Famous Peole with Polydactyly- Oprah Winfrey - Halle Berry- Kate Hudson

Everything you need to know about the genetic disease!

GLI3GLI3 is the gene that causes polydactyly, and it is located on the seventh chromosome. GLI3 is one of the multiple genes that deal with tissue and organ formation during the embryo stages of a human. The protein that GLI3 codes for is a part of the C2-H2 zinc finger, and it is 41,960,948 to 42,237,869 base pairs long. GLI3 has not been recorded as being sequenced.

What is Polydactyly?Polydactyly refers to a disorder where one has more than five fingers or toes on a hand or foot. Because the extra fingers or toes are in one's bone structure initially, it is considered a congenital anomaly. The disease was discovered by Tyler Hayden, and instances of polydactyly can be dated back to 1100-1500 AD. The beginning stages of polydactyly occur in one out of every five hundred people.

What Causes Polydactyly?Polydactyly has an autosomal dominant inheritance pattern. If one person in a couple has polydactyly, the couple’s offspring has a 50% chance of also having polydactyly. Because polydactyly isn’t a sex linked trait, males and females have the same chance of acquiring it.

Types of PolydactylyPre-axial Polydactyly Pre-axial polydactyly is a type of polydactyly where the growth of extra digits occurs on the larger side of the hand or feet, i.e. the big toe or thumb. This type of polydactyly is the most common in people of an Asian ethnicity, and is also common in people with Down syndrome. Isolated Post-axial PolydactylyIn this form of the disease, the extra digit is on the small side of the hand/foot, meaning the pinky/pinky toe side. Isolated post-axial polydactyly is most common in African Americans, and the 7p13 gene is the location of the mutations.

Testing and TreatmentPolydactyly requires no testing, because the symptoms are obvious, making the diagnosis easily given. To treat polydactyly, there are two common options. The first is a vascular clip, which is used when there is no bone growth in the extra digit, only tissue. In this form of treatment, a vascular clip is attached to the growth, stopping the blood flow to it, and causing it to eventually fall off. The second form of treatment is surgery, for those whose extra digit has a bone growth. The surgery usually takes place at a young age while the bones are not nearly fully developed, and the complexity, and specificity of the surgery correlates to the severity of the condition.


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