Neuromuscular Junction

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by linds0607
Last updated 7 years ago

Human Anatomy

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Neuromuscular Junction

Neuromuscular Junction

What is it?

Tranmission of Nerve Impulse



How it Works

Work Cited

Marieb, Elaine N. "The Muscular System." Essentials of Human Anatomy ' Physiology. 10th ed. San Francisco: Pearson, 2011. 181-219. Print.

The Sliding Filament Mechanism

The neuromuscular junction is the association site of axon terminals of the motor neuron and muscle.

When an action potential reaches a neuromuscular junction, the calcium channels open and calcium ions enter the axon terminal. This causes synaptic vesicles to release acetylcholine. Acetylcholine then attaches to the receptors on the sarcolemma of the muscle. In response to the binding of ACh to a receptor, the sarcolemma becomes permeable to sodium. Sodium then rushes into the cell generating an action potential and potassium leaves the cell. Once started, muscle contraction cannot be stopped.

Nerve activation causes myosin heads to attach to thin filaments. They then bind to the more filaments, pulling them to the center of the sarcomere. This continuing action causes a sliding of myosin along the actin, thus creating muscle contraction.


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