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Brand Names/ Trade Names

Lorazepam is a benzodiazepine derivative used as an sedative-hypnotic, anticonvulsant, anxiolytic, and muscle relaxant. Lorazepam binds to GABA receptor in the CNS and facilitates the action of GABA, which is an inhibitory neurotransmitter. Benzodiazepines heighten the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to chloride, therefore leading to membrane hyperpolarization, which is thought to facilitate sedative/hypnotic/antivulsant/muscle relaxant properties of the benzodiazepines.

Routes of admission:Oral and Injection

Mechanism of Action


ReferencesLorazepam. Entanercept. Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. Available at: http://www.micromedexsolutions.com. Accessed September 25, 2015.Connor, West. "Lorazepam." YouTube. YouTube, 28 Mar. 2008. Web. 01 Oct. 2015.

Interesting Fact

"The drugs propofol and lorazepam [Ativan, a benzodiazepine sedative] were found to be the primary drugs responsible for Mr. Jackson's death. Other drugs detected were: Midazolam [Versed], Diazepam [Valium], Lidocaine, and Ephedrine."

AtivanLorazepam Intensol

Drug ClassMainly -->* Antianxiety *Anticonvulsant *BenzodiazepineBenzodiazepine, Short or Intermediate ActingCentral Nervous System AgentMusculoskeletal AgentSkeletal Muscle Relaxant

Indications-used for treatment of anxiety and insomnia-treatment of status epilepticus-preanesthetic medication-treatment for chemotherapy-induced nausea and vomiting

Contradictions-Injection of Loarazepam may result inrteriospasm resulting in gangrene via intraarterial administration,-respiratory insufficiency-sleep apnea syndrome-hypersensitivity to benzodiazepines or any component of the product (polyethylene glycol, propylene glycol, or benzyl -acute narrow angle glaucoma

Adverse Effects:Cardiovascular: Hypertentsion, hypotension Dermatologic: Erthyema, injection site pain, rash Endocrine/Metabolic: Acidosis, hypoosmolarity, *Gastrointestinal: Nausea and vommitingHematologic: Leukopenia, ThrombocytopeniaHepatic: JaundiceImmunologic: Anaphylaxis, Hypersensitivity reactionNeurologic: Dizziness, memory impairment, headache, seizures, sedation, sleep disorderPsychiatric: Depression, delerium

Precautions-abrupt discontinuation can lead to withdrawal symptoms -risk of heavy sedation and possible airway obstruction-increased risk of potentially fatal respiratory depression associated with CNS depressant and alcohol use-if lorazepam is abruptly withdrawn increased risk of convulsions/seizures -Respirtatory function compromised with COPD and sleep apnea syndrome-Personality disorders can lead to increased risk of drug dependence-higher doses and prolonged use can lead to physical and physiological dependance


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