Lisa's HMB300 Glog (Depression and the Lateral Habenula)

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by lisanham
Last updated 6 years ago


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Lisa's HMB300 Glog (Depression and the Lateral Habenula)

The lateral habenula (LHb) has become a region of interest in the pathophysiology of depression, as it has consistently been found to be hyperactive in both depressed humans and animal models of depression.

Virus-induced over-expression of βCaMKII in the LHb of wild-type rodents produced symptoms of depression, including anhedonia and despair. Down-regulating βCaMKII or blocking its function reduced these symptoms.

A quantitative proteomic analysis revealed significant up-regulation of βCaMKII in the LHb of congenitally learned helpless rats, a well-accepted model of depression. In these rats, βCaMKII levels were almost two times greater than the wild-type control.

These findings, therefore, identify a key role for βCaMKII and the LHb in depression, and should provide new insights for the treatment of depression.

Over-expression of βCaMKII enhances synaptic activity and increases the spike output of LHb neurons—hyperactivity like that observed in depression. Knocking-down βCaMKII had the opposite effect.