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Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia(IBMPFD)


This disease will inevitably lead to the prognosis of extreme weakness, organ failure, or even death fortunatley this disease can be treated with certain therapies such as root cell therapy in which cells from a healthy human are implemented into the diseased induvidual to help there body recorrect itself. Or simply medicines to help bad cells or proper dietry and physical therapy.



"Inclusion body myopathy with onset Paget disease and frontotemporal dementia."Genetics Home Reference. U.S. National Library of Medicine®, 15 Febuary 2015. Web. 26 Febuary 2015"WHAT IS INCLUSION BODY MYOPATHY ASSOCIATED WITH PAGET'S DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA (IBMPFD)?" CENTER FOR MOLECULAR AND MITOCHONDRIAL MEDICINE AND GENETICS(MAMMAG).Web. 1Mar. 2015"Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice." NCBI. U.S. National Library of Medicine, National Institutes of Health, 2013. Web. 1 Mar. 2015All pictures provided by

fig.1 this disease primarily deteriorates muscular mass (dystrophy) starting at the joint area of main appendages.fig.2 the disease additionally weakens bones, aswell as deforming them.fig.3 the disease weakens the heart for it is a muscle (cardiovascular) and weakens the muscle that make the lungs function, the diaphragm

This disease has the frequency to effect one out of every million people. Commonly in this number of people they are of any age, overweight, or inactive males.




This disease can cause traumatic damage and effects consisting of: muscular deterioration, brittle, painful, or deformed bones, weakness of appendages, respitory and vascular difficulties, problems, and failure.

This disease was found in Japan around the year of 2003 while founder, Dr. Wai-Kwan tang was studying various valosin containing protiens in genes. He had found a additional disease to the five he already found in the general "VCP hotspot" in the gp132 section in the chromosome. After analyzing the disease he composed a good conception of this disease. This disease was mainly a dystropy of the muscle (muscle deterioration), with a rare cases additional atrophy of the mentality and skeletal system of the induvidual with the disease.

This mutation causes the VCP gene to malfunction. This gene allows the ability to interact with certain protiens this disease cuts off the ability and then it leaves behind excess cells making obstructions or lack of cells.


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