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by SallyYao
Last updated 7 years ago

Health & Fitness

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Picture citation:http://www.intechopen.com/haemophilia-the-bleeding-bad-gene.html


sex chromo w/ hemophilia gene


Hemophilia is a rare genetic bleeding disorder in which the clotting process could not function properly when the blood vessel is damaged. (Mayo)


Normally, blood is pumped by heart to travel around the body through blood vessels. When bleeding, platelets (a type of blood cell) come out to plug the holes. Then a type of protein called clotting factors in plasma "clot over the plugs". However, clotting factors in people with hemophilia are either missing or deficient. Thus the lack of the protein leads to the difficulty of forming the clot that could effectively stop the bleeding. (WFH)



Since the disorder is recessive, girls would mostly likely to be carriers than get affected. If a father has the disease, he can only make his daughter to be a carrier but won't affect his son at all, since father contributes X to daughter, Y to son. Also, because girls have 2 X chromos, it is rare for both X to have the disorder; whereas boys have a X and a Y, since the disorder occurs on X, they are more likely to be affected if his mother is a carrier. (WFH)

... To Be Continued ...



Hemophilia is a sex-linked recessive disease that could either be inherited or get through mutations. There are 3 types, the most common one is Hemophilia A (lack of factor VIII), another one is Hemophilia B (lack of factor IX), and the last one is Hemophilia C (lack of factor XI; also called Von Willebrand Disease). The disorder is located on X chromosome, both A&B mostly affect boys, and can only be passed down through mothers to boys. However, Hemophilia C can be inherited from either parents and occur in both boys and girls. In addition, there's no clear evidence for ethnic prevalence. (Mayo)

"Each year in US, about 400 babies are born with Hemophilia , which affects 1 in 5,000 male births. (CDC) But in general, 1 in 10,000 people are born with it. (WFH) "



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