[2015] Wyly Andrews: Hemophilia A

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by rastreich
Last updated 6 years ago

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[2015] Wyly Andrews: Hemophilia A


Hemophilia A is a hereditary disorder which causes a person to bleed a lot more than a person without hemophilia. Cuts cause unreasonable amounts of bleeding, and the body can begin bleeding at seemingly random.

Cause of Hemophilia A:

Hemophilia A can be easily spotted for its excessive amounts of bleeding, but also causes:NosebleedsBruisingBleeding for an unknown reasonBlood alongside fecal matterTightness in a joint (blood swells up around and in a joint)

Hemophilia A is always transferred through the X gene. That means when the mom has hemophilia, she can have a son with hemophilia, but if the dad has hemophilia, the child can only get hemophilia if it's a girl.

Symptoms of Hemophilia A:

How does it work?

Hemophilia A is caused by a deficiency of the FVIII protein, which is used to clot up cuts. A person is considered to have hemophilia A if he has less than 50% the normal FVIII in their blood.

Treatment for Hemophilia A:

Someone who is affected with Hemophilia A needs the one thing they have a deficiency in: FVIII. Donated plasma or lab created FVIII concentrate are the two best ways to prevent Hemophilia A symptoms.

Researchers have begun working on a new kind of gene therapy, which is leading to some advances in treating Hemophilia A. So far, testing has only been on animals but are hoping to advance research to humans. For more information, go to: http://www.sciencedaily.com/releases/2013/12/131210152529.htm?utm_source=rss&utm_medium=rss&utm_campaign=new-gene-therapy-proves-promising-as-hemophilia-treatment

400 males are born with Hemophilia A a year. As of December, 2013, researchers say that about 50,000 people in the United States are affected and millions of more in the world.

How common?

Hemophilia A is a recessive genetic disorder, linked to the X sex gene. That means that males are more prone to getting it, while a female needs both X genes to be hemophiliac in order for her to develop Hemophilia A.Hemophilia A can also be a spontaneous mutation, or a mutation of the gene, which accounts for 30% of cases.

Research Efforts

By Wyly Andrews


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