Friedrich Miescher and the Nucleic acid

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by JavierFrancisco
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Friedrich Miescher and the Nucleic acid

Miescher studies played an important role in molecular biology, which opened the door to numerous tests and experiments. Although at the time the term nuclein wasn´ttoo known and he never proposed it as the DNA we know today. Experimental studies of nucleic acids constitute a major part of modern biological and medical research, and form a foundation for genome and forensic science

Friedrich Miescherand the Nucleic acid

Johannes Friedrich Miescher, born the 13 August 1844 in Basel Switzerland was a Swiss physician and biologist. Miescher is known for beign the first researcher to isolate and identify nucleic acid in 1869. He died of tuberculosis in 1895 aged 51.

Nucleic acids are biopolymers essential for all known forms of life. They are made from monomers known as nucleotides. Together with proteins, nucleic acids are the most important biological macromolecules: their function is encoding, transmitting and expressing genetic information.

Miescher experiment

Why was Miescher experiment so important ?

Each nucleotide has three components: a 5-carbon sugar, a phosphate group, and a nitrogenous base. If the sugar is deoxyribose, the polymer is DNA. If the sugar is ribose, the polymer is RNA.

The nucleic acids composition

. Miescher was a medical student in the Hoppe-Seyler's laboratory, his teacher, began analyzing the remains of pus from surgical waste, isolating the nuclei of white blood cells and extracting the acid and loaded with phosphorus substance to which he called "nuclein"

The analysis of this precipitate showed it was a complex material containing, nitrogen and phosphorus. The proportions were different from any other biological material studied. He concluded that there was isolated a previously undescribed biological component.


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