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by savagesam
Last updated 6 years ago

Health & Fitness

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In the FMR1 gene, people normally have 6 to 50 repeats of the trinucleotide CGG. Others however with over 200 repeats of CGG have parts of their FMR1 gene methylated which turns the gene off and causes Fragile X syndrome. To sum up, Fragile X syndrome is caused by epigenetics. People with this syndrome have lower intelligence and autistic behavior. This disease is expressed in the X chromosome.

The two main epigenetical chemical changes that happen in the chromosome are histone modifications and DNA methylation. Histone modification is when histones are changed after translation, impacting the way chromatin is arranged. DNA methylation is when a methyl group (CH3) is added to DNA. Both of these chemcial changes trigger epigenetical changes.

The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence, or in other words how the environment changes how genes are expressed.

Epigenetics and IQ

- http://www.whatisepigenetics.com/fundamentals/-http://learn.genetics.utah.edu/content/epigenetics/control/-http://www.nature.com/scitable/topicpage/epigenetic-influences-and-disease-895-

References here

Experiment Template

Specific chemical changes

What is epigenetics?


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