Disease: Prostate Cancer

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by Tahaira94
Last updated 4 years ago

Discipline:
Health & Fitness
Subject:
Health

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Disease: Prostate Cancer

During Doctor Valerie Odero-Marah's prostate cancer research she found that when SNAIL was overexpressed it Peroxidasin is also overexpressedSNAIL is a protein that in humans is encoded by the SNAI1 geneSNAIL protein plays the role of inducing EMT in prostate cancer cellsEpithelial-mesenchymal transition (EMT) is a process by which cancer cells invade and migratePeroxidasin is a protein coding gene thatencodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formationThe research that is being done by Doctor Marah's lab is an investigation of her hypothesis that Snail increases peroxidasin to promote perineuralinvasion Conclusion Snail overexpression in prostatecancer cells may promote perineuralinvasion and there is still testing to bedone to see if peroxidasin isinvolved

the delivery of DNA or RNA into eukaryotic cells — is a powerful tool used to study and control gene expression.Types of transfection:Transient transfectionDNA is introduced into the nucleus of the cell, but does not integrate into the chromosome. Stable transfectionthe transfected DNA is either integrated into the chromosomal DNA or maintained as an episome

Disea e

Transfection

Peroxidasin

uses antibodies to detect its specific antigen.The specificity of the antibody-antigen interaction enables a target protein that have been separated based on size by gelelectrophoresis to be identified in the midst of a complex protein mixture extracted from cells.

Western Blot

SNAIL Peroxidasin&Prostate Cancer

Video

the maintenance and growth of the cells of multicellular organisms outside the body in specially designed containers and under precise conditions of temperature, humidity, nutrition, and freedom from contaminationallowes scientists to use cultures of cells for experimental studies and for biological assays of many types.

Trypan Blue

Cell Culture

Glog by: Tahaira James

is a vital stain used to selectively colour dead tissues or cells blue. While live cells or tissues with intact cell membranes are not colouredTrypan blue is used for cell countingThough widely used (TB) has limitations.

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