Cystic Fibrosis

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by indystruve
Last updated 7 years ago

Health & Fitness

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Cystic Fibrosis

•Inherited chronic disease effecting lungs and digestive system•Effects 70,000 people worldwide•Clogs the lungs and leads to life threatening lung infections and can also obstruct the pancreas and stops natural enzymes from helping the body break down and absorb food

Cause: Defect in the CFTR gene. This gene makes a protein that controls the movement of salt in and out of your body’s cells. In people with CF, this gene makes a protein that does not function very well causing thick sticky mucus and very salty sweat. Other gene defects may effect the severity .

Symptoms: very salty-tasting skin; persistent coughing, at times with phlegm; frequent lung infections; wheezing or shortness of breath; poor growth/weight gain in spite of good appetite; difficulties with bowel movements

Correct mechanism: When the CFTR gene is unaffected and is functioning properly it produces a chloride ion channel that is important in creating sweat, digestive juices, and mucus. Incorrect Mechanism: Different mutations can affect the severity of CF. Sodium and chloride are not moved throughout cells properly and that can cause problems. The production of thick sticky mucus can block narrow passages of affected organs. These organs are the lungs, pancreas, and intestines. This mucus can also lead to other infectictions in these organs.

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Cystic Fibrosis

•Cell signal pathway affected: Peroxisome proliferators-activated receptor-y


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