Craig Venter: Expressed Sequence

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Craig Venter: Expressed Sequence

Craig Venter: Expressed Sequence Tags (ESTs)

The Scientist

About Genetics and DNA Sequencing

Genetics generally concerns heredity and organism variation

DNA sequencing is a technique known as electrophoresis used to separate pieces of DNA that differ in length by one base. DNA is made up of four bases that define the gene. Once the DNA is identified and analyzed, scientists can look for flaws, or mutations that could cause disease. This is where ESTs come in.

The Discovery

Craig Venter had previously been involved in neurochemistry research, has developed the use of auomated gene sequences, been a professor of pharmacology and therapuetics, and a section cheif at the National Institutes of Health (NIH). The NIH, infact, was where he did all of his research about gene tagging, and worked with other scientists to better his discoveries.

Craig Venter invented ESTs based on the development of complementary DNA (cDNA)- a more basic fundamental sequencing system. Other traditional methods of gene sequencing already known were the Vitek or API 2ONE systems. Few human genes have actually been identified and mapped before this discovery.

In 1990

For science, ESTs are an efficient way to find genes and explore their functions. They help to:-identify new genes-map the human genome-show the accuracy of sequencing technology


For mankind, ESTs have already helped map the whole human genome, as showed right. They also may result in the discovery of diagnosis and treatment of many diseases such as diabetes or Alzheimer's.

-Shampo, Marc, and Kyle, Robert. "J. Craig Venter—The Human Genome Project"., Ian. "DNA Sequencing". Author. "J. Craig Venter (1946-) describes a fast new approach to gene discovery using Expressed Sequence Tags (ESTs)" "J. Craig Venter"





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