Acid-Bases: Health & Aging

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by RobbieMurphy
Last updated 5 years ago

Health & Fitness

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Acid-Bases: Health & Aging

Acid-Base Project: Health & Aging



Robbie Murphy / Zac Collum

Acid-Base Balance

Disorders of acid-base balance can lead to severe complications in many disease states.

Arterial blood pH is normally closely regulated to between 7.35 and 7.45. Maintaining the pH within these limits is achieved by bicarbonate, other buffers, the lungs and the kidneys.

Acid-base disorders are commonly encountered in clinical practice and can have a substanctial impact on a patient's prognosis and outcome. The elderly are more prone to develop acid-base disturbances than the young. With age, the kidney undergoes structural and functional changes that limit the adapaptive mechanisms responsible for maintaining acid-base homeostasis.

Serum [H+] is maintained within a narrow range through a series of reversible chemical buffers and physiologic pulmonary and renal responses. Although the pH of the extracellular fluid is maintained between 7.38-7.42 in elderly, there is evidence to suggest this occurs at the expense of a reduced serum HCO3 reserve.There is a significant increase in the steady-state blood [H+] and a reduction in steady-state serum HCO3 from subjects aged 20-100, suggesting a progressive age-related, low-level metabolic acidosis.

As aging occurs, a human's health deteriorates, often accompanied by disease. Such disease may be achieved by disorders in acid-base balance, possibly resulting in conditions such as acidosis, alkolosis, etc.



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